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Microfluidics for Processing of Biomaterials.

Luca Gasperini1,2, Alexandra P Marques3,4,5, Rui L Reis3,4,5

  • 13B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative, Braga, Portugal. luca.gasperini@i3bs.uminho.pt.

Advances in Experimental Medicine and Biology
|April 15, 2020
PubMed
Summary
This summary is machine-generated.

Microfluidics enables processing of natural biomaterials like polysaccharides and proteins. This review covers techniques for water-soluble polymers, focusing on their crosslinking and sol-gel properties for microfluidic applications.

Keywords:
HydrogelsMicrofabricationMicrofluidics

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Area of Science:

  • Biomaterials Science
  • Chemical Engineering
  • Polymer Science

Background:

  • Microfluidics offers precise control for processing diverse biomaterials.
  • Natural polymers, particularly water-soluble ones, are crucial for advanced applications.
  • Understanding material properties is key to successful microfluidic fabrication.

Purpose of the Study:

  • To review microfluidic processing of natural origin biomaterials.
  • To focus on water-soluble polymers that form non-flowing phases post-crosslinking.
  • To highlight key material characteristics impacting microfluidic processability.

Main Methods:

  • Discussion of microfluidic techniques for biomaterial processing.
  • Analysis of critical properties of selected natural polymers.
  • Evaluation of material suitability based on sol-gel transition mechanisms.

Main Results:

  • Identification of key polysaccharides (e.g., alginate, chitosan) and proteins (e.g., collagen, gelatin) for microfluidics.
  • Characterization of properties influencing processability, such as viscosity and crosslinking behavior.
  • Matching specific microfluidic techniques to different sol-gel transition mechanisms.

Conclusions:

  • Microfluidics is a versatile tool for fabricating structures from natural polymers.
  • Material properties significantly dictate the choice of microfluidic technique.
  • This review provides a guide for selecting appropriate polymers and methods for microfluidic applications.