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Role of Non-coding RNA in Diabetic Cardiomyopathy

Lu Xia1, Meiyi Song2

  • 1Division of Gastroenterology and Hepatology, Digestive Disease Institute, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, China.

Advances in Experimental Medicine and Biology
|April 15, 2020
PubMed

Insights

Diabetic cardiomyopathy (DCM) involves heart dysfunction. Non-coding RNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are key regulators in DCM, offering potential therapeutic targets for heart failure.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Diabetic cardiomyopathy (DCM) is a primary cause of morbidity and mortality in diabetic patients globally.
  • DCM is characterized by cardiomyocyte hypertrophy, apoptosis, and myocardial fibrosis, leading to heart failure.
  • Non-coding RNAs (ncRNAs) are emerging as critical regulators in various human diseases, including DCM.

Purpose of the Study:

  • To summarize current research on the role of ncRNAs in the pathological processes of diabetic cardiomyopathy.
  • To highlight the regulatory functions of microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) in DCM.
  • To discuss the potential of ncRNAs as therapeutic targets for treating DCM and improving heart function.

Main Methods:

  • Literature review of recent research on ncRNAs in diabetic cardiomyopathy.
  • Analysis of the specific roles of miRNAs, lncRNAs, and circRNAs in DCM pathogenesis.
  • Synthesis of evidence regarding the protective effects of ncRNAs on cardiac function.

Main Results:

  • MicroRNAs (miRNAs) have demonstrated regulatory roles in insulin resistance, cardiomyocyte apoptosis, and inflammation associated with DCM.
  • Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) have increasingly prominent functions in DCM, influencing its progression.
  • Non-coding RNAs play significant roles in the pathological mechanisms underlying DCM.

Conclusions:

  • Non-coding RNAs are crucial in the development and progression of diabetic cardiomyopathy.
  • Targeting ncRNAs presents promising therapeutic strategies for managing DCM and preventing heart failure.
  • Further research into ncRNAs will advance our understanding and treatment of diabetic cardiomyopathy.

Keywords:
Diabetes mellitusDiabetic cardiomyopathyHeart failureNon-coding RNA

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