Related Experiment Video
Updated: Dec 24, 2025
12:28
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
18.0K
The many facets of brain aging.
Lars Nyberg1,2,3, Anders Wåhlin1,3
1Umeå center for Functional Brain Imaging, Umeå University, Umeå, Sweden.
Elife
|April 17, 2020
Summary
Big data analysis of brain images from over 18,000 individuals reveals how aging impacts the brain. This research provides new insights into age-related brain changes.
Area of Science:
- Neuroscience
- Gerontology
- Data Science
Background:
- Aging is a complex biological process affecting all organ systems, including the brain.
- Understanding age-related brain changes is crucial for developing interventions to maintain cognitive health.
Purpose of the Study:
- To investigate the influence of aging on brain structure and function using big data analytics.
- To identify key biomarkers and patterns associated with brain aging.
Main Methods:
- Utilized big-data analytic techniques on a large dataset of brain images (n=18,707).
- Applied advanced imaging processing and statistical modeling to analyze neuroimaging data.
Main Results:
- Identified significant age-related alterations in various brain regions.
- Correlated specific imaging features with chronological age and cognitive status.
Conclusions:
- Big data analytics applied to neuroimaging is a powerful tool for studying brain aging.
- Findings contribute to a deeper understanding of the aging brain and potential targets for intervention.
More Related Videos
10:13Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
Published on: February 14, 2014
14.1K
08:29Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
Published on: December 18, 2016
14.4K
Related Concept Videos
01:30Cognitive Development During Adulthood
683
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
683
01:26Aging
514
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
514
01:26Alzheimer's Disease: Overview
1.5K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.5K
01:30Organization of the Brain
2.1K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
2.1K
01:19The Effect of Aging on Tissues
3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K
01:14Role of Cerebellum and Prefrontal Cortex in Memory
911
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
911