Related Experiment Video

Updated: Dec 23, 2025

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model
04:55

Author Spotlight: Simulating Pediatric Cardiac Surgery Using a Neonatal Piglet Model

Published on: May 26, 2023

1.2K

[Research advances in cardiovascular system damage caused by SARS-CoV-2 in children]

Hai-Hui Xiao1, Xin Wang, Yi Xu

  • 1Department of Pediatric Cardiovasology, Children's Medical Center, Second Xiangya Hospital, Central South University, Changsha 410011, China. ch.wang@163.com.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|April 22, 2020
PubMed

Insights

Coronavirus disease 2019 (COVID-19) increasingly affects children, potentially causing cardiovascular damage. This review explores SARS-CoV-2

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Cardiology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, continues to spread globally.
  • Children represent a growing demographic of COVID-19 cases.
  • SARS-CoV-2 infection presents with diverse symptoms, including potential cardiovascular complications.

Purpose of the Study:

  • To review and discuss the potential cardiovascular system damage in children due to SARS-CoV-2 infection.
  • To explore the underlying mechanisms of SARS-CoV-2-induced cardiovascular injury in pediatric populations.
  • To aid in the timely prevention and treatment strategies for pediatric cardiovascular complications.

Main Methods:

  • Systematic literature review.
  • Analysis of existing research on SARS-CoV-2 and pediatric cardiovascular health.
  • Synthesis of findings on clinical manifestations and pathogenic mechanisms.

Main Results:

  • Evidence suggests SARS-CoV-2 can impact the cardiovascular system in children.
  • Potential mechanisms include direct viral invasion, inflammatory responses, and immune-mediated injury.
  • Observed cardiovascular manifestations range from arrhythmias to myocarditis.

Conclusions:

  • SARS-CoV-2 poses a risk of cardiovascular complications in children.
  • Understanding the mechanisms is crucial for effective clinical management.
  • Further research is needed to refine prevention and treatment protocols for pediatric cardiovascular involvement.

More Related Videos

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-208:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

3.2K
Simultaneous 3D Analysis of Cardiac Damage and Immune Response in Reperfused Acute Myocardial Infarction Using Light Sheet Fluorescence Microscopy06:38

Simultaneous 3D Analysis of Cardiac Damage and Immune Response in Reperfused Acute Myocardial Infarction Using Light Sheet Fluorescence Microscopy

Published on: September 26, 2025

920

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
781
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
291
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
293
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
343
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
332