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Updated: Dec 23, 2025

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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Regulation of Plasma Cell Differentiation.

W Ise1, T Kurosaki2,3

  • 1Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Osaka, 565-0871, Japan. wise@ifrec.osaka-u.ac.jp.

Advances in Experimental Medicine and Biology
|April 24, 2020
PubMed
Summary

Long-lived plasma cells, crucial for long-term immunity, develop from germinal center (GC) B cells. This review explores the cellular and molecular mechanisms driving plasma cell differentiation from GC B cells.

Keywords:
AntibodyB cellGerminal centerPlasma cellTranscription factor

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Humoral immunity relies on antibodies produced by plasma cells.
  • Plasma cells differentiate from activated B cells and are key antibody secretors.
  • Long-lived plasma cells, essential for sustained protection, primarily originate from germinal center (GC) responses.

Purpose of the Study:

  • To review recent advancements in understanding plasma cell differentiation.
  • To elucidate the cellular and molecular underpinnings of plasma cell development from GC B cells.

Main Methods:

  • Literature review of recent scientific progress.
  • Analysis of cellular and molecular mechanisms involved in B cell differentiation.

Main Results:

  • Germinal center B cells are major precursors for long-lived plasma cells.
  • Specific cellular and molecular pathways govern plasma cell differentiation from GC B cells.

Conclusions:

  • Understanding plasma cell differentiation from GC B cells is critical for long-term humoral immunity.
  • Further research into these pathways can inform strategies for enhancing protective immunity.