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Animal Models and Renal Biomarkers of Diabetic Nephropathy

Laura Pérez-López1, Mauro Boronat1,2, Carlos Melián1,3

  • 1Institute of Biomedical and Health Research (IUIBS), University of Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Spain.

Advances in Experimental Medicine and Biology
|April 25, 2020
PubMed

Keywords:
Animal modelsChronic kidney diseaseCreatinineCystatin CDiabetes mellitusDiabetic nephropathyEarly markersGlomerular filtration rateKidney injury molecule-1ObesitySymmetric dimethylarginine

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Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...