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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Related Experiment Video

Updated: Dec 23, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

HPMA-based polymeric conjugates in anticancer therapeutics.

Sarita Rani¹, Umesh Gupta¹

¹Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer, Rajasthan, 305817, India.

Drug Discovery Today

|April 26, 2020

Summary

This summary is machine-generated.

N-(2-hydroxypropyl) methacrylamide (HPMA) shows promise as a polymer for drug delivery in cancer therapy. While HPMA-drug conjugates are under investigation, further research is needed for successful clinical application.

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Area of Science:

Polymer chemistry and drug delivery systems.
Biomedical applications of advanced polymer architectures.

Background:

Polymer therapeutics are increasingly important for disease treatment.
N-(2-hydroxypropyl) methacrylamide (HPMA) offers unique structural properties for conjugation.

Purpose of the Study:

To review the development and capabilities of HPMA and HPMA-drug conjugates for cancer therapy.
To evaluate HPMA as a potential alternative to polyethylene glycol (PEG) in biomedical applications.

Main Methods:

Review of existing literature on HPMA synthesis and drug conjugation.
Analysis of structural properties and versatility of HPMA for biomedical applications.
Examination of ongoing clinical trials for HPMA-drug conjugates.

Main Results:

HPMA's structural design makes it a versatile platform for creating polymeric conjugates.
HPMA presents a viable alternative to polyethylene glycol (PEG) for biomedical uses.
Multiple clinical trials involving HPMA-drug conjugates are currently underway.

Conclusions:

HPMA-drug conjugates demonstrate significant potential in cancer therapy.
Despite ongoing trials, no HPMA-based therapeutic products have reached the market.
Further research is essential to translate HPMA-drug conjugate potential into successful cancer therapeutics.