[PREDICTION OF THE SEVERITY OF ALLERGODERMATHOSIS COMPLICATED BY STAPHYLOCOCCAL INFECTION]

In the presence of numerous trigger factors contributing to the exposure of allergodermathosis, there is significant heterogeneity in the phenotypic manifestations of the disease, the severity of its course, as well as the co-morbidity and response to therapy. Objective - to assess the possibility of predicting the severity of allergodermathosis complicated by staphylococcal infection, taking into account the patients' clinical and medical history, bacteriological and immunological indicators. The study included 252 patients with allergodermathosis (95 with atopic dermatitis (AD) and 157 with true eczema (TE)), who were admitted for treatment to the Department of Dermatology of the SE "Institute of Dermatology and Venerology of the National Academy of Medical Sciences of Ukraine" in 2016 - 2019. They carried out the clinical severity scoring of patients using the SCORAD scale, for AD and EASI for TE, bacteriological and immunological analysis with determination of the levels of specific IgE for Staphylococcus aureus auto-strains. It was found that as the severity of the course of allergodermathosis increased, the dysbiotic changes in the skin microbiocenosis increased, which is especially noticeable in patients with severe AD and TE: the isolation frequency of S. aureus strains in this group of patients exceeded the control group 7-11 times in the study of affected areas and 5-10 times in the study of intact ones. The definition of adhesive activity indicators showed that high indices were determined in the group of strains isolated from damaged skin areas of patients with allergodermathosis: AIA - (3.47±0.21) bacteria / erythrocyte and IAM - (4.22±0.32) bacteria / erythrocyte. It was revealed that the severity of the course of allergodermathosis correlated with the levels of specific IgE for S. aureus auto-strains.