Related Experiment Video

Updated: Dec 22, 2025

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia
05:32

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia

Published on: January 19, 2022

4.9K

[Primary Ciliary Dyskinesia - Interdisciplinary Diagnostics and Therapy]

Stephan Hackenberg, Agmal Scherzad

    Laryngo- Rhino- Otologie
    |May 9, 2020
    PubMed

    Insights

    Primary ciliary dyskinesia (PCD) is a rare genetic disorder causing respiratory issues from birth. Diagnosis involves complex tests, and management requires specialized multidisciplinary care.

    Area of Science:

    • Genetics
    • Respiratory Medicine
    • Pediatrics

    Background:

    • Primary ciliary dyskinesia (PCD) is a rare, genetically diverse condition.
    • Symptoms manifest early, including neonatal respiratory distress, situs inversus, chronic cough, and male infertility.
    • Recurrent sinonasal disorders and bronchiectasis are common manifestations.

    Purpose of the Study:

    • To provide a comprehensive overview of current diagnostic procedures for PCD.
    • To outline the available therapeutic options for managing PCD.
    • To emphasize the importance of specialized, multidisciplinary care centers for PCD patients.

    Main Methods:

    • Review of current diagnostic techniques for PCD.
    • Assessment of established and emerging therapeutic strategies.
    • Synthesis of expert recommendations for PCD management.

    Main Results:

    • Diagnostic complexity necessitates a combination of methods: transmission electron microscopy, nasal nitric oxide assessment, high-speed video microscopy, and genetic testing.
    • Management strategies are evolving but require a coordinated, multidisciplinary approach.
    • Early and accurate diagnosis is crucial for effective long-term patient outcomes.

    Conclusions:

    • PCD diagnosis is challenging due to its heterogeneity and requires a multi-faceted approach.
    • Effective management of PCD is best achieved in specialized centers with multidisciplinary teams.
    • Ongoing research is vital for improving diagnostic accuracy and therapeutic interventions for PCD.

    More Related Videos

    Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic09:03

    Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic

    Published on: November 7, 2020

    5.3K
    Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo08:00

    Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

    Published on: July 13, 2015

    12.5K

    Related Concept Videos

    Mechanism of Ciliary Motion01:05

    Mechanism of Ciliary Motion

    The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
    The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
    4.6K
    Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

    Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

    Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
    Medical History
    3.0K
    Cystic Fibrosis: Management01:24

    Cystic Fibrosis: Management

    Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
    Sinus disease and chronic...
    373
    Direct-Acting Cholinergic Agonists: Therapeutic Uses01:11

    Direct-Acting Cholinergic Agonists: Therapeutic Uses

    Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren...
    1.4K
    Parkinson's Disease: Treatment01:24

    Parkinson's Disease: Treatment

    Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
    Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
    852
    Chronic Obstructive Pulmonary Disease-I: Introduction01:20

    Chronic Obstructive Pulmonary Disease-I: Introduction

    Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
    3.4K