Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Intraoperative Lipoproteins Associated with Postoperative Delirium in a Prospective Observational Study of Older Adults Undergoing Cardiac Surgery.

Journal of cardiothoracic and vascular anesthesia·2026

Same author

Iterative Cytoreductive Surgery and HIPEC for Peritoneal Metastases from Primary Appendiceal and Colorectal Cancers: An Observational Study.

Cancers·2025

Same author

Pancreatic Cancer Screening in New-onset and Deteriorating Diabetes: Preliminary Results From the PANDOME Study.

The Journal of clinical endocrinology and metabolism·2025

Same author

Minimally invasive vs. open radical cholecystectomy for gallbladder cancer: 30-day NSQIP outcomes analysis.

Surgical endoscopy·2025

Same author

Exploration of Benign and Malignant Gastric Surgery.

The Surgical clinics of North America·2024

Same author

Selective Sentinel Node Dissection in Melanoma with Trends and Future Directions.

Cancers·2024

Search research articles

Related Experiment Video

Updated: Dec 21, 2025

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Peritoneal Cancers and Hyperthermic Intraperitoneal Chemotherapy.

Eric Pletcher¹, Elizabeth Gleeson², Daniel Labow³

¹Surgery Department, Mount Sinai West and Morningside, 425 West 59th Street, 7th Floor, New York, NY 10019, USA.

The Surgical Clinics of North America

|May 14, 2020

Summary

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy offers a potentially curative treatment for peritoneal malignancies. This aggressive approach removes visible tumors and delivers chemotherapy directly to the abdomen to target microscopic disease, improving survival in select patients.

Keywords:

Colorectal Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Ovarian cancer Peritoneal carcinoma index Peritoneal mesothelioma Peritoneal metastasis Pseudomyxoma peritonei

More Related Videos

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Related Experiment Videos

Last Updated: Dec 21, 2025

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Area of Science:

Oncology
Surgical Oncology
Gastroenterology

Background:

Peritoneal malignancies, including primary and secondary cancers, present significant treatment challenges.
Locoregional disease requires aggressive management strategies to improve patient outcomes.
Cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is a specialized treatment modality.

Purpose of the Study:

To describe the aggressive, potentially curative approach of cytoreductive surgery and HIPEC for peritoneal malignancies.
To outline the indications and methodology for this complex surgical and chemotherapeutic intervention.
To highlight its role in improving overall survival for select patient populations.

Main Methods:

Involves complete resection of all macroscopic disease larger than 2.5 mm.
Followed by direct instillation of hyperthermic chemotherapy into the peritoneal cavity.
Aims to maximize drug exposure to microscopic disease within the peritoneum.

Main Results:

Demonstrates an aggressive, potentially curative approach for locoregional peritoneal disease.
Achieves higher drug exposure to microscopic disease through direct peritoneal instillation.
Can increase overall survival in carefully selected patients.

Conclusions:

Cytoreductive surgery and HIPEC represent a vital treatment option for specific peritoneal cancers.
The procedure is indicated for primary peritoneal mesothelioma, pseudomyxoma peritonei, colorectal, appendiceal, and ovarian cancers without extra-abdominal metastasis.
Careful patient selection with limited peritoneal involvement is crucial for successful outcomes and improved survival.