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Updated: Dec 21, 2025
Utilization of Stop-flow Micro-tubing Reactors for the Development of Organic Transformations
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Application of Transition-Metal Catalysis, Biocatalysis, and Flow Chemistry as State-of-the-Art Technologies in the
Xingxian Gu1, Jibin Zhao1, Like Chen1
1Suzhou Novartis Technical Development Co., Ltd., #18-1 Tonglian Road, Bixi Subdistrict, Changshu City, Jiangsu Province 215537, P.R. China.
Abstract:
LCZ696 is a novel treatment for patients suffering from heart failure that combines the two active pharmaceutical ingredients sacubitril and valsartan in a single chemical compound. While valsartan is an established drug substance, a new manufacturing process suitable for large-scale commercial production had to be developed for sacubitril. The use of chemocatalysis, biocatalysis, and flow chemistry as state-of-the-art technologies allowed to efficiently build up the structure of sacubitril and achieve the defined performance targets.
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