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LED&Paper-based analytical device for phosphatemia/calcemia diagnostics☆.

Marta Fiedoruk-Pogrebniak¹, Robert Koncki¹

¹University of Warsaw, Faculty of Chemistry, Pasteura 1, 02-093 Warsaw, Poland.

Journal of Pharmaceutical and Biomedical Analysis

|May 16, 2020

Summary

A new paper-based device enables simultaneous, low-cost detection of orthophosphate and calcium ions, crucial for diagnosing hyperphosphatemia outside clinical labs. This portable, user-friendly tool offers fast, non-infectious waste disposal.

Keywords:

Calcium Fluorescence LEDs Orthophosphate Paper-based device

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Area of Science:

Analytical Chemistry
Biomedical Engineering
Materials Science

Background:

Hyperphosphatemia diagnosis relies on monitoring orthophosphate and calcium ion levels.
Existing diagnostic methods often require specialized laboratory equipment and trained personnel.
There is a need for portable, low-cost, and user-friendly diagnostic tools for point-of-care use.

Purpose of the Study:

To develop a prototype paper-based analytical device for simultaneous determination of orthophosphate and calcium ions.
To create a low-cost, portable, and user-friendly diagnostic tool for hyperphosphatemia.
To validate the device's utility in clinical settings for calcemia/phosphatemia diagnostics.

Main Methods:

A laboratory-on-paper device was fabricated using wax printing on filter paper for simultaneous analyte detection.
The device integrates two-analyte disposable paper strips with LED-based fluorescence detectors and a voltmeter.
The system was tested using control serum standards and real human serum samples.

Main Results:

The paper-based analytical device achieved low detection limits of 1.4 μmol L⁻¹ for orthophosphate and 7.4 μmol L⁻¹ for calcium ions.
The developed device is miniature, extremely low-cost, portable, and user-friendly, enabling use outside specialized clinical laboratories.
Successful demonstration of practical utility for calcemia/phosphatemia diagnostics using serum samples.

Conclusions:

The developed LED & Paper-based analytical device offers a promising solution for rapid, on-site hyperphosphatemia diagnostics.
The disposable, user-friendly nature and non-infectious waste ensure suitability for point-of-care applications.
This technology facilitates accessible and efficient monitoring of critical ion levels for patient health management.