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Glycosylated hemoglobin is associated with systemic inflammation, hypercoagulability, and prognosis of COVID-19

Zhenzhou Wang1, Zhe Du1, Fengxue Zhu1

  • 1Trauma Center, National Center for Trauma Medicine, Key Laboratory of Trauma and Neural Regeneration, Peking University People's Hospital, Beijing 100044, China.

Diabetes Research and Clinical Practice
|May 17, 2020
PubMed

Insights

High glycosylated hemoglobin (HbA1c) levels in COVID-19 patients correlate with increased inflammation and poorer prognosis. Monitoring HbA1c aids in assessing COVID-19 severity and patient outcomes.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Endocrinology

Background:

  • Diabetes mellitus is a known risk factor for severe COVID-19.
  • The interplay between glycosylated hemoglobin (HbA1c), inflammation, and COVID-19 prognosis remains under-explored.

Purpose of the Study:

  • To investigate the association between HbA1c levels and markers of inflammation, hypercoagulability, and oxygen saturation in COVID-19 patients.
  • To evaluate the prognostic value of HbA1c in COVID-19 patients.

Main Methods:

  • Retrospective analysis of 132 COVID-19 patients who had HbA1c testing.
  • Collected demographic, clinical, laboratory, and outcome data.
  • Categorized patients into three groups based on blood glucose status.

Main Results:

  • Significant differences in SaO2, serum ferritin, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen (Fbg), and IL6 levels were observed across groups.
  • Elevated HbA1c correlated positively with serum ferritin, CRP, Fbg, and ESR.
  • A negative correlation was found between HbA1c and SaO2.

Conclusions:

  • High HbA1c levels are linked to inflammation, hypercoagulability, and reduced oxygen saturation in COVID-19 patients.
  • COVID-19 patients with diabetes exhibit a higher mortality rate (27.7%).
  • HbA1c measurement post-admission is valuable for assessing COVID-19 patient prognosis.
Abstract

Keywords:
COVID-19DiabetesHbA1cInflammationPrognosis

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