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Related Experiment Video

Updated: Dec 20, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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Epigenetics in Primary Sjögren's Syndrome.

Anne Bordron1, Valérie Devauchelle-Pensec1,2, Christelle Le Dantec1

  • 1INSERM U1227, «Lymphocyte B et autoimmunité», Labex Igo "Immunotherapy Graft, Oncology", Réseau épigénétique du cancéropole Grand Ouest, Université de Brest, Brest, France.

Advances in Experimental Medicine and Biology
|May 24, 2020
PubMed
Summary
This summary is machine-generated.

Epigenetic factors, including DNA methylation and microRNA changes, are crucial in primary Sjögren

Keywords:
DNA methylationEpigeneticsEpithelial cellsGeneticsHistoneSjögren’s syndromemicroRNAs

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Area of Science:

  • Immunology
  • Genetics
  • Epigenetics

Background:

  • Primary Sjögren's syndrome (SjS) is a chronic autoimmune disease affecting exocrine glands, predominantly in women.
  • The exact causes of SjS are not fully understood, but epigenetic factors are increasingly recognized as significant contributors.
  • Epigenetics involves inheritable gene expression changes independent of DNA sequence mutations.

Purpose of the Study:

  • To explore the role of epigenetic modifications in the development and progression of primary Sjögren's syndrome.
  • To identify specific epigenetic mechanisms implicated in SjS pathogenesis.

Main Methods:

  • Analysis of epigenetic modifications in minor salivary glands and lymphocytes from SjS patients.
  • Epigenome-wide association studies (EWAS) to identify genetic and epigenetic links.
  • Investigation of DNA methylation, nucleosome positioning, and microRNA alterations.

Main Results:

  • Abnormal DNA methylation was observed, leading to the defective control of repressed genes, including autoantigens and X chromosome genes.
  • Altered nucleosome positioning correlated with autoantibody production.
  • Dysregulation of microRNA was identified as a key feature.
  • EWAS highlighted the involvement of interferon and calcium signaling pathways.

Conclusions:

  • Epigenetic modifications, such as aberrant DNA methylation and microRNA dysregulation, play a critical role in SjS.
  • These reversible epigenetic changes offer potential therapeutic targets for Sjögren's syndrome.
  • Understanding epigenetic mechanisms provides insights into SjS etiology and progression.