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Determination of amiodarone hydrochloride in pharmaceutical formulations by derivative UV spectrophotometry and
A M Di Pietra1, V Cavrini, R Gatti
1Department of Pharmaceutical Sciences, University of Bologna, Italy.
Pharmaceutical Research
|November 1, 1988
Abstract:
Assay procedures based on derivative ultraviolet spectrophotometry and high-performance liquid chromatography (HPLC) have been developed for the specific determination of amiodarone hydrochloride in pharmaceutical dosage forms. The use of first- and second-order derivative spectrophotometry was found to have suppressed the background absorption from the excipients with comparable accuracy and precision to the reversed-phased HPLC reference method. A conventional UV absorption method (lambda = 242 nm) is subject to possible interference by formulation excipients.