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Updated: Dec 20, 2025

Study of the Functions and Activities of Neuronal K-Cl Co-Transporter KCC2 Using Western Blotting
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OATP1B3 Expression and Function is Modulated by Coexpression with OCT1, OATP1B1, and NTCP.

Yuchen Zhang1, Melissa Ruggiero1, Bruno Hagenbuch2

  • 1Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas.

Drug Metabolism and Disposition: the Biological Fate of Chemicals
|June 3, 2020
PubMed
Summary

Organic anion transporting polypeptide (OATP) 1B3 interacts with other transporters like organic cation transporter (OCT) 1, affecting its expression and function. These interactions highlight potential over- or underestimations in drug-drug interaction studies using single transporter systems.

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