Rapid and on-site detection of multiple fentanyl compounds by dual-ion trap miniature mass spectrometry system
Related Experiment Video
Updated: Dec 19, 2025

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs
Published on: November 8, 2024
Manqing Kang1, Ru Lian2, Xiaoyang Zhang3
1State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing, 100084, China.
Abstract:
With the increasing abuse of fentanyl and its derivatives, it is urgent to develop techniques that can rapidly detect these compounds in different types of matrices. In this work, we developed a miniature mass spectrometer-based method for the fast and on-site analysis of fentanyl compounds. Optimization of several direct sampling procedures such as paper capillary spray cartridge with a miniature mass spectrometry system enables sensitive analysis of multiple fentanyl compounds. This system was evaluated by analysis of fentanyl and its derivatives in several types of beverage, showing limits of detection (LODs) as low as 10 ppb. It has also been applied into analysis of fentanyl compounds on the surface of a dusty plastic bag, showing LODs of 1 ng/cm2. A precursor ion scan method was also developed for fast screening of multiple fentanyl compounds. This system has also been applied in the analysis of fentanyl in urine samples.
More Related Videos
10:17High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
11:14Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
Published on: October 2, 2016
Related Concept Videos
High-Performance Liquid Chromatography: Types of Detectors
Mass Analyzers: Common Types
Mass Spectrometry: Complex Analysis
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
Tandem Mass Spectrometry
Gas Chromatography: Types of Detectors-II
Peptide Identification Using Tandem Mass Spectrometry
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...