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Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Aminoglycosides are a class of antibiotics used to treat various bacterial infections. Clinicians must determine the elimination rate constant (k) and volume of distribution (VD) to optimize therapeutic efficacy and minimize toxicity. The k value represents the rate at which the drug is removed from the body, and the VD reflects the degree to which the drug distributes into body tissues. Accurately estimating these parameters allows healthcare professionals to tailor drug dosing to individual...
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Local Anesthetics: Adverse Effects01:12

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While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
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This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
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Related Experiment Video

Updated: Dec 18, 2025

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
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Amoxicillin-Induced Aseptic Meningitis.

Débora Sousa1, Pedro Raimundo1

  • 1Internal Medicine Department, Hospital da Luz, Lisboa, Portugal.

European Journal of Case Reports in Internal Medicine
|June 12, 2020
PubMed
Summary
This summary is machine-generated.

Aseptic meningitis is a rare side effect of amoxicillin, a common antibiotic. This case highlights the importance of considering drug-induced reactions when symptoms like fever and headache appear after amoxicillin use.

Keywords:
Aseptic meningitisamoxicillindrug-induced aseptic meningitis

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Area of Science:

  • Pharmacology
  • Neurology
  • Infectious Diseases

Background:

  • Amoxicillin, a widely prescribed penicillin-class antibiotic, is generally well-tolerated.
  • Hypersensitivity reactions to amoxicillin can occur, ranging in severity.
  • Aseptic meningitis is an exceptionally rare adverse effect associated with amoxicillin use.

Purpose of the Study:

  • To report a case of amoxicillin-induced aseptic meningitis.
  • To emphasize the importance of recognizing drug-induced aseptic meningitis.
  • To contribute to the limited literature on this rare adverse reaction.

Main Methods:

  • Case report of a 63-year-old male presenting with fever and headache.
  • Analysis of cerebrospinal fluid suggestive of aseptic meningitis.
  • Review of patient history for previous similar episodes linked to amoxicillin.

Main Results:

  • The patient developed symptoms after initiating amoxicillin prophylaxis for a dental procedure.
  • Cerebrospinal fluid analysis indicated aseptic meningitis.
  • Symptoms resolved rapidly upon discontinuation of amoxicillin.
  • A similar episode was noted in the patient's history following amoxicillin treatment for *Helicobacter pylori*.

Conclusions:

  • Aseptic meningitis is a rare but potential adverse effect of amoxicillin.
  • Diagnosis involves excluding other causes and establishing a temporal link between amoxicillin administration and symptom onset.
  • The underlying mechanism is believed to be an immunologic hypersensitivity reaction.