Related Experiment Video

Updated: Dec 18, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

17.8K

Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future Directions

Marie Helena Docherty1,2, David P Baird1,2, Jeremy Hughes1,2

  • 1Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.

Frontiers in Pharmacology
|June 13, 2020
PubMed

Insights

Cellular senescence, a state of irreversible growth arrest, contributes to organ dysfunction and aging. This review explores senescent cells

Area of Science:

  • Cellular and Molecular Biology
  • Gerontology
  • Pathology

Background:

  • Cellular senescence is a state of irreversible growth arrest with altered gene expression and a pro-inflammatory secretome.
  • Acutely senescent cells are vital for physiological processes like wound repair and cancer defense.
  • Accumulated senescent cells contribute to organ dysfunction, fibrosis, and aging.

Purpose of the Study:

  • To review the role of senescent cells in promoting progressive fibrosis and dysfunction, particularly in the kidney.
  • To highlight differences between healthy and senescent cells.
  • To summarize pharmacological strategies for senescent cell depletion or manipulation.

Main Methods:

  • Literature review of cellular senescence and its role in organ dysfunction.
  • Analysis of cellular phenotypes and secretomes.
  • Summary of experimental pharmacological interventions.

Main Results:

  • Senescent cells accumulate due to aging, stress, and damage, leading to organ dysfunction and fibrosis.
  • Specific cellular and molecular differences exist between healthy and senescent cells.
  • Pharmacological approaches show promise in managing senescent cells for organ preservation.

Conclusions:

  • Senescent cell accumulation is a key driver of age-related organ dysfunction and fibrosis.
  • Targeting senescent cells offers potential therapeutic strategies for aging and injury.
  • Further research is needed for clinical translation of senolytic therapies.
Keywords:
agingfibrosiskidneypharmacokineticspharmacotherapeutic approachesregenerationsenescence

More Related Videos

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

24.8K
Techniques to Induce and Quantify Cellular Senescence06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

34.7K

Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.2K
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
261
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
453
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
711
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
19.2K
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
200