THE PECULIARITIES OF AVERAGE VALUES OF THE INDICES OF NON-VIRUS LABORATORY MARKERS OF ACTIVE EPSTEIN-BARR VIRUS...

Epstein Barr Virus (EBV) originates from the subgroup of herpes viruses which have infected more than 90,0 % of adults worldwide. A special importance is attached to its affection of the patients with Systemic Lupus Erythematosus (SLE). We still have not found out which indices of active virus infection for SLE patients are the most productive and informative. We have involved 120 patients with the diagnosis of SLE. The results of the evaluation of changes in blood parameters indicate that in patients with active EBV infection the average hemoglobin content is significantly lower, and the average number of monocytes, the average content of AlT, C-RP, total protein and γ-globulins is significantly higher than in patients without active EBV infection. There are also significantly higher values of anti-dsDNA and ANA in patients in the experimental group and a lower average value of the total complement, which may indicate a negative effect of the active virus on the immune system in patients with SLE. The patients with SLE with active EBV infection have the features of the average values of non-viral laboratory markers which are reliably higher than for those infected without active virus replication and they are the indices of hyperalaninamino- transferaseemia, the content of C-reactive protein, of the average caption of antibodies to double-stranded deoxyribonucleic acid and the caption of antinuclear antibodies; the average values of the indices of average content of hemoglobin are also reliably lower as well as the index of a total complement. The regularities of changes of the indices of the conducted research discovered in the process of our research allow us to suspect active EBV Infection for the patients with SLE. The ultimate verification of this needs the application of direct serological tests.