BONE MINERAL DENSITY AND THE PREVALENCE OF ITS DISORDERS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND SYNTROPIC...

The state of bone mineral density has not been properly examined yet in patients with systemic lupus erythematosus (SLE) and the pathogenetically associated syntropic comorbid lesions of organs and systems. In a randomized manner, after stratification by the presence of SLE, we enrolled 123 premenopausal women aged 21 to 51 years into the study. Patients with SLE, depending on the diagnosed pathogenetically associated syntropic comorbid lesions of organs and systems, were stratified into twenty groups (with hemorrhagic vasculitis, capillaritis, Raynaud syndrome, atherosclerosis, livedo reticularis, venous thrombosis, myocarditis, secondary hypertension, stable angina, pneumonitis, pneumosclerosis, autoimmune hepatitis, steatohepatitis, chronic pancreatitis, aseptic bone necrosis, arthralgia, myalgia, autoimmune thyroiditis, obesity, and alopecia). The bone mineral density (BMD) was determined for patients in each group through dual-energy X-ray absorptiometry (DXA) scans of the lumbar spine and proximal femur, taking into account the worst T-score result. Having analyzed the data from densitometric examinations of 20 patient groups, we arrived at the following conclusions: a) all patients from seven groups (with hemorrhagic vasculitis, capillaritis, stable angina, autoimmune hepatitis, steatohepatitis, aseptic bone necrosis, autoimmune thyroiditis) had reduced BMD disorders, and the largest proportion of patients with normal BMD were from the group with syntropic venous thrombosis; b) there was only one group of patients (with stable angina) without the cases of the first degree osteopenia, and the largest proportion of such patients was in the group with syntropic venous thrombosis; c) there was only one group of patients (with aseptic bone necrosis) without the cases of the second degree osteopenia, and the largest proportion of such patients was in the group with stable angina; d) there were patients with the third degree osteopenia in all groups, and the largest proportion of the third degree osteopenia cases was in the group with stable angina; e) there were no cases of osteoporosis in groups with syntropic venous thrombosis and stable angina, and the largest proportion of osteoporosis cases was in the groups with syntropic autoimmune hepatitis; the prevalence of osteoporosis is significantly higher than the prevalence of normal BMD and the first degree osteopenia in patients with atherosclerosis and chronic pancreatitis; the prevalence of osteoporosis is also significantly higher that the prevalence of normal BMD and all degrees of osteopenia in patients with autoimmune hepatitis.