In Vitro and Animal Models for SARS-CoV-2 research

Area of Science:

• Virology
• Pathophysiology
• Infectious Diseases

Background:

• Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes COVID-19.
• Understanding SARS-CoV-2 pathophysiology is key for drug development.
• Reliable research models are needed to study viral infection and disease.

Purpose of the Study:

• To review current cell lines, organoids, and animal models for SARS-CoV-2 research.
• To highlight the importance of these models in understanding COVID-19.

Main Methods:

• Literature review of existing research models.
• Categorization of models based on biological system (cell lines, organoids, animals).

Main Results:

• Identified various cell lines, organoids, and animal models used in COVID-19 research.
• These models vary in their ability to replicate viral life cycle and pathology.

Conclusions:

• Appropriate model selection is critical for advancing SARS-CoV-2 basic research.
• Continued development of advanced models will accelerate the discovery of effective treatments for COVID-19.