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Roles for Phospholipase D1 in the Tumor Microenvironment
Daniela Barisano1, Michael A Frohman2
1Center for Developmental Genetics and the Department of Pharmacological Sciences, Stony Brook University School of Medicine, Stony Brook, NY, USA.
Advances in Experimental Medicine and Biology
|June 25, 2020
Summary
Phospholipase D (PLD) plays a role in cancer, not just within tumor cells but also in the tumor microenvironment. This review explores PLD
Area of Science:
- Biochemistry
- Cancer Biology
- Signal Transduction
Background:
- Phospholipase D (PLD) is a lipid-modifying enzyme implicated in cancer for decades.
- Early research focused on PLD's role within tumor cells.
- Emerging evidence highlights PLD's involvement in the tumor microenvironment.
Purpose of the Study:
- To review the multifaceted roles of PLD, particularly PLD1, in cancer.
- To explore PLD's functions within the tumor microenvironment.
- To discuss limitations and provide cautionary notes on PLD research.
Main Methods:
- Literature review of existing studies on Phospholipase D (PLD) in cancer.
- Analysis of research on PLD's impact on tumor microenvironment components.
- Critical evaluation of methodologies and findings in PLD research.
Main Results:
- PLD influences neoangiogenesis, nutrient supply, and immune response.
- PLD affects platelet interactions with circulating cancer cells.
- PLD is involved in exosome biology within the tumor microenvironment.
Conclusions:
- PLD, especially PLD1, has significant roles beyond tumor cells, impacting the tumor microenvironment.
- Further research is needed to fully elucidate PLD's complex functions in oncogenesis.
- Caution is advised in interpreting PLD studies due to model system limitations.
Keywords:
AutophagyBreast cancerCardiovascularExosomesImmune responsesInhibitorLipid signalingMetastasisNeoangiogenesisPLD1PLD2Phospholipase DPlateletsTumor microenvironmentVEGFMore Related Videos
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