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Updated: Dec 17, 2025
08:31
A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
Published on: October 16, 2021
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The PASCAL Device-Early Experience with a Leaflet Approximation Device: What Are the Benefits/Limitations Compared
Noé Corpataux1, Mirjam Gauri Winkel1, Mohammad Kassar1
1Department of Cardiology, Bern University Hospital, University of Bern, 3010, Bern, Switzerland.
Current Cardiology Reports
|June 29, 2020
Summary
The Edwards PASCAL system offers a new transcatheter approach for mitral and tricuspid valve repair in patients ineligible for surgery. Early data suggest comparable safety and efficacy to existing devices.
Area of Science:
- Cardiology
- Medical Devices
- Interventional Cardiology
Background:
- Transcatheter mitral and tricuspid valve leaflet approximation addresses regurgitation in patients unsuitable for surgery.
- Existing systems have limitations, necessitating novel approaches.
- The Edwards PASCAL system presents an alternative transcatheter valve repair device.
Purpose of the Study:
- To review the technical aspects of the Edwards PASCAL transcatheter valve repair system.
- To summarize the current clinical evidence for the PASCAL system.
Main Methods:
- Review of technical features of the Edwards PASCAL device.
- Analysis of early clinical data and safety/efficacy outcomes.
- Comparison with existing transcatheter mitral and tricuspid valve repair systems.
Main Results:
- The PASCAL system provides a novel transcatheter approach for mitral and tricuspid valve repair.
- Early data indicate safety and efficacy comparable to the Abbott MitraClip system.
- The device may overcome limitations of previous systems and allow patient-specific anatomical adaptation.
Conclusions:
- The Edwards PASCAL system is a promising addition to transcatheter valve repair options.
- Further randomized trials and long-term data are required to validate its efficacy and safety.
- The system holds potential for treating patients with mitral and tricuspid regurgitation not eligible for surgery.
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