[Stress-induced disorders]

Area of Science:

• Neuroscience
• Psychiatry
• Pharmacology

Background:

• Acute and chronic stress significantly impact health, leading to various diseases.
• Stress pathogenesis involves an imbalance between sympathetic and parasympathetic nervous systems.
• Numerous organ systems, including cardiovascular, respiratory, immune, skin, and gastrointestinal, are affected by stress.

Purpose of the Study:

• To analyze diseases and conditions resulting from acute and chronic stress.
• To elucidate the pathogenesis of stress-induced disorders.
• To identify protective agents against stress-related damage.

Main Methods:

• Review of existing literature on stress and its physiological effects.
• Analysis of the role of the sympathetic and parasympathetic nervous systems in stress response.
• Examination of the neurochemical mechanisms involved in stress adaptation.

Main Results:

• Stress significantly impacts cardiovascular, respiratory, immune, skin, and gastrointestinal systems.
• Gamma-aminobutyric acid (GABA) is identified as a key mediator in stress limitation.
• GABA protects the nervous system and target organs from stress-induced damage.

Conclusions:

• Imbalance in stress systems contributes to various stress-related disorders.
• Aminophenylbutyric acid hydrochloride, a GABA analogue, demonstrates protective effects.
• Aminophenylbutyric acid hydrochloride is a well-tolerated option for mitigating stress impacts in adults and children.