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Updated: Dec 15, 2025

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
Published on: April 29, 2013
[Imaging of the peripheral nervous system].
Lorenz Grunder1, Roman Guggenberger1, Moritz C Wurnig1
1Institut für Diagnostische und Interventionelle Radiologie, Universitätsspital Zürich.
Advanced imaging techniques now aid in diagnosing neuropathies. Radiology, including ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI), provides crucial localization and distribution data for effective patient management.
Area of Science:
- Radiology
- Neurology
- Medical Imaging
Background:
- Radiology's role in clinical practice has expanded due to technical advancements.
- Electrophysiology is a sensitive method for diagnosing neuropathies.
- Imaging complements electrophysiology in evaluating neuropathies.
Purpose of the Study:
- To present the capabilities and value of various imaging modalities for peripheral neuropathies.
- To highlight how imaging aids in diagnosing and evaluating neuropathies.
- To emphasize the importance of imaging in patient management.
Main Methods:
- Review of imaging modalities including ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI).
- Discussion of therapy-relevant information obtainable through imaging.
- Focus on neurography for diagnostic certainty.
Main Results:
- Imaging provides essential information on neuropathy localization, cause, and distribution.
- Neurography enhances diagnostic certainty in neuropathy cases.
- Different imaging modalities offer distinct advantages in evaluating peripheral nerves.
Conclusions:
- Imaging is increasingly vital for the diagnosis and evaluation of neuropathies.
- Ultrasound, CT, and MRI are valuable tools in neurography.
- Radiological assessment is a key component in managing patients with neuropathy.
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