Related Experiment Video
Updated: Dec 15, 2025
04:05
Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
Published on: October 6, 2023
677
Best Time for Levothyroxine Intake in Ramadan (THYRAM): Basrah Experience
Ibrahim Abbood Zaboon1, Haider Ayad Alidrisi2, Ibrahim Hani Hussein1
1Faiha Specialized Diabetes, Endocrine, and Metabolism Center (FDEMC), Basrah Health Directorate, Basrah, Iraq.
Summary
Fasting during Ramadan does not significantly impact thyroid stimulating hormone (TSH) levels in patients taking levothyroxine (L-thyroxine). The timing of L-thyroxine intake, whether pre-iftar, post-iftar, or pre-suhoor, showed no significant differences in TSH control.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Public Health
Background:
- Ramadan fasting requires daytime abstinence from oral intake.
- Hypothyroidism patients need levothyroxine (L-thyroxine) on an empty stomach.
- Administering L-thyroxine during Ramadan presents timing challenges due to fasting restrictions.
Purpose of the Study:
- To determine the optimal timing for levothyroxine (L-thyroxine) intake during the fasting month of Ramadan.
Main Methods:
- A prospective study involving 50 primary hypothyroidism patients over three months.
- Patients were divided into three groups based on L-thyroxine intake timing: pre-iftar, post-iftar, and pre-suhoor.
- Thyroid stimulating hormone (TSH) levels were monitored before and after Ramadan.
Main Results:
- No significant changes in TSH levels were observed within or among the three groups.
- TSH control frequencies post-Ramadan showed no significant differences across the study groups.
- Both patients with initially controlled and uncontrolled TSH maintained similar control rates regardless of intake timing.
Conclusions:
- Levothyroxine (L-thyroxine) intake at pre-iftar, post-iftar, or pre-suhoor times during Ramadan does not significantly affect TSH control.
- The timing of L-thyroxine administration during Ramadan can be flexible without compromising thyroid hormone regulation.
More Related Videos
Related Concept Videos
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
265
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
265
01:25Dosage Regimen: Multiple Oral Dosage
132
Understanding how a drug's concentration fluctuates within the body over time is crucial in pharmacokinetics, particularly with multiple oral doses. A graphical representation of multiple oral dosages provides insight into these dynamics. Typical accumulation curves of a drug's concentration in the body reveal a sawtooth pattern, indicating periodic peaks and troughs correlating with each dose administration and the drug's subsequent elimination.The plasma concentration at any time during an...
132
01:15Bioavailability Study Design: Healthy Subjects Versus Patients
71
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
71
01:19Dosage Interval and Administration Route: Determination Methods
121
A medication’s effectiveness largely depends on its appropriate dosage and the route of administration. Dosage ensures that a sufficient drug concentration is maintained in the bloodstream to elicit the desired therapeutic effect without causing toxicity. The route of administration affects the drug's bioavailability, rate of absorption, and onset of action, which are crucial for achieving optimal therapeutic outcomes. Drug dosage calculations are critical to tailoring therapy to...
121
01:24Dosage Regimen: Individualization
103
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
103
01:21Drug Dosing: Obese Patients
145
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
145