Related Experiment Video
Updated: Dec 15, 2025
07:02
In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
7.7K
Interleukins in Thyroid Cancer: From Basic Researches to Applications in Clinical Practice
Chuang Xi1, Guo-Qiang Zhang1, Zhen-Kui Sun1
1Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Frontiers in Immunology
|July 14, 2020
Summary
Interleukins, key signaling proteins, are deeply involved in thyroid cancer development and progression. This review explores their mechanisms and clinical applications in managing thyroid cancer.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- Inflammation significantly impacts cancer development and progression.
- Interleukins, produced by T lymphocytes, are crucial for intercellular communication.
- Interleukins are increasingly recognized for their role in thyroid cancer.
Purpose of the Study:
- To review the mechanisms of interleukins in thyroid cancer.
- To highlight the clinical applications of interleukins in thyroid cancer diagnosis, prognosis, and treatment.
Main Methods:
- Literature review of studies on interleukins and thyroid cancer.
- Analysis of interleukin functions in thyroid cancer cell proliferation and migration.
- Examination of preclinical and clinical research on interleukin applications.
Main Results:
- Interleukins influence thyroid cancer cell proliferation and migration.
- Interleukins show potential in distinguishing benign from malignant thyroid diseases.
- Interleukins may aid in risk prediction, prognosis evaluation, and recurrence monitoring.
Conclusions:
- Interleukins play a multifaceted role in thyroid cancer.
- Further research into interleukins offers promising avenues for clinical practice in thyroid cancer management.
Related Concept Videos
01:27Tumor Immunotherapy
1.6K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.6K
01:20Synthesis and Regulation of Thyroid Hormones
6.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
6.7K
01:27Cytotoxic T Cells-mediated Immune Response
6.3K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.3K
02:49Cancer Therapies
9.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
01:18Functions of Thyroid Hormones
4.6K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
4.6K
02:17The Tumor Microenvironment
7.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.5K