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Updated: Dec 14, 2025

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
Published on: November 1, 2018
Autophagy and Glomerular Diseases
Jing Cui1, Xueyuan Bai1, Xiangmei Chen2
1Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing, China.
Abstract:
Autophagy is an endogenous and essential process which maintains cellular homeostasis and directs cell fate. The glomerular diseases are one main part of the kidney diseases, often associated with poor clinical outcomes. The regulation of autophagy contributes to the progression of various glomerular diseases, including focal segmental glomerulosclerosis, lupus nephritis, and so on. For example, it has been demonstrated that prevention of autophagic flux in the kidney epithelium and podocytes is sufficient to trigger a degenerative disease of the kidney with many of the manifestations of human FSGS. We review the roles of autophagy in glomerular diseases. Therapies in clinical use, and in preclinical or clinical development, are also discussed in relation to their effects on autophagy in glomerular diseases.
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