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Updated: Dec 14, 2025

A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
SEPSIS: IMPORTANCE OF ETHNIC PROPERTIES AND PHENOTYPES (REVIEW)
L Ratiani1, K Machavariani1, V Shoshiashvili1
1Tbilisi State Medical University, First University Clinic; Research Institute of Clinical Medicine, Department of anesthesiology and intensive care, Tbilisi, Georgia.
Abstract:
Sepsis is a common and potentially lethal syndrome. Its global prevalence is rising during last decades, which is related to older population, comorbidities, such as diabetes, malignancies and increased numbers of interventions. Currently there is no specific treatment for sepsis. Lethal outcome is depending under several factors, such as site of infections, infectious agent, severity of sepsis, organ dysfunction, age, sex, social and economic factors, race and ethnicity. Severe sepsis is related to about 30% of lethality but outcome is not always predictable according to severity of sepsis. This paradox can be explained on basis of genetic, ethnic, race and phenotype properties of patient. Influence of these factors on sepsis outcome is not yet properly investigated. Future studies are needed for definition of correlation between different race, nation, genetic and phenotype properties and on this basis will be possible the development of more effective personal treatment of septic patients.
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