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[BONE METABOLISM AND BONE MINERAL DENSITY IN CHILDREN WITH RECURRENT BRONCHITIS]

L Ovcharenko1, S Dmitrieva1, A Vertehel1

  • 1SI "Zaporizhzhya Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine".

Georgian Medical News
|July 17, 2020
PubMed

Insights

Children with recurrent bronchitis show altered bone metabolism and decreased bone mineral density (BMD). This study highlights vitamin D deficiency and increased bone resorption in these children.

Area of Science:

  • Pediatrics
  • Bone Metabolism
  • Respiratory Health

Background:

  • Recurrent bronchitis (RB) is a common childhood illness.
  • Bone health is crucial for overall child development.
  • The relationship between RB and bone metabolism requires further investigation.

Purpose of the Study:

  • To assess bone metabolism and bone mineral density (BMD) in children diagnosed with recurrent bronchitis.
  • To compare bone health markers between children with RB and healthy controls.

Main Methods:

  • Examined 120 children aged 6-10 years, divided into two groups: 60 with RB and 60 controls.
  • Measured serum levels of alkaline phosphatase, osteocalcin, collagen type 1 degradation products, parathyroid hormone, and 25(OH)D.
  • Utilized Dual-energy X-ray Absorptiometry (DXA) to assess bone mineral density (BMD) at various skeletal sites.

Main Results:

  • Children with RB exhibited significantly higher alkaline phosphatase, osteocalcin, collagen type 1 degradation products, and parathyroid hormone levels compared to controls.
  • A higher prevalence of vitamin D deficiency (serum 25(OH)D < 30 ng/ml) was observed in children with RB (59.3% increase).
  • DXA scans revealed decreased BMD in a significant percentage of children with RB across lumbar vertebrae and femur neck regions.

Conclusions:

  • Children with recurrent bronchitis demonstrate an activated bone resorption process.
  • Vitamin D deficiency is prevalent in children with RB and is associated with decreased bone mineral density.
  • Findings suggest a link between recurrent bronchitis and compromised bone health in children.

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