Related Experiment Video
Updated: Dec 14, 2025
04:09
Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
3.5K
Stem Cells: A Golden Therapy for Diabetic Wounds
Shubhangi Buchade1, Shivani Desai1, Ramesh Bhonde2
1Department of Pharmacology, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pune, India.
Current Diabetes Reviews
|July 18, 2020
Summary
Diabetes mellitus complications, like diabetic foot ulcers, impair healing. This review explores stem cell therapy as a promising treatment to improve outcomes for diabetic wound healing.
Area of Science:
- Endocrinology and Metabolic Science
- Regenerative Medicine
- Wound Healing Research
Background:
- Diabetes mellitus is a leading global cause of mortality, associated with severe organ system complications.
- Diabetic foot ulcers affect 15-25% of patients, characterized by impaired wound healing mechanisms.
- Current treatments for diabetic foot complications have limited success rates.
Purpose of the Study:
- To review the pathogenesis and complications of diabetes mellitus.
- To investigate the potential role and benefits of stem cell therapy in managing diabetic wounds.
Main Methods:
- Literature review of diabetes pathogenesis and complications.
- Exploration of stem cell applications in diabetic wound management.
- Analysis of existing research on stem cell benefits for diabetic wounds.
Main Results:
- Diabetes significantly impairs wound healing through various molecular and cellular pathways.
- Stem cell therapy presents a novel approach to address the complex pathophysiology of diabetic wounds.
- Early research indicates potential benefits of stem cells in promoting diabetic wound healing.
Conclusions:
- Stem cell therapy holds significant promise for improving diabetic wound healing outcomes.
- Further research is warranted to optimize stem cell-based treatments for diabetic complications.
- Understanding stem cell mechanisms is crucial for advancing diabetes care.
Related Concept Videos
01:19Clinical Applications of Epidermal Stem Cells
3.1K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.1K
01:23Tissue Renewal without Stem Cells
2.0K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
However, failure of such a system...
2.0K
01:17Stem Cell Culture
5.9K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.9K
01:21Stem Cell Therapy for Tissue Regeneration
4.5K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.5K
01:22iPS Cell Differentiation
3.0K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.0K
01:19Mesenchymal Stem Cells
5.3K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.3K