[Asthenic disorders. History and modernity]

Area of Science:

• Neurology
• Internal Medicine
• Psychiatry

Background:

• Asthenia, or persistent fatigue, is a common and complex condition.
• It significantly impacts patient quality of life and healthcare burden.
• Understanding its multifaceted nature is crucial for effective management.

Purpose of the Study:

• To review current literature on asthenic disorders.
• To synthesize information on etiology, pathogenesis, and clinical presentations.
• To outline contemporary treatment approaches for asthenia.

Main Methods:

• Comprehensive literature search of publications on asthenic disorders.
• Analysis of studies focusing on causes and mechanisms of asthenia.
• Review of clinical manifestations and treatment strategies.

Main Results:

• Multiple etiological factors contribute to asthenia.
• Pathogenesis involves complex neurobiological and systemic mechanisms.
• Asthenia presents distinct clinical features in various underlying diseases.

Conclusions:

• Asthenic disorders require a comprehensive understanding of their diverse origins.
• Integrated treatment approaches are necessary for managing asthenia effectively.
• Further research into pathogenesis may yield novel therapeutic targets.