DNA Damage Response and Metabolic Reprogramming in Health and Disease

Area of Science:

• Molecular Biology
• Cellular Biology
• Genetics

Background:

• Nuclear DNA damage is linked to aging and diseases like cancer.
• The DNA damage response (DDR) was traditionally viewed as a nuclear process.
• Emerging evidence highlights DDR's broader cellular and systemic roles.

Purpose of the Study:

• To review the extranuclear and systemic functions of the DDR.
• To discuss how DDR signaling impacts cellular homeostasis and survival.
• To explore DDR's role in health and disease beyond nuclear DNA repair.

Main Methods:

• Literature review of recent studies on DDR.
• Analysis of signaling pathways involved in DDR.
• Integration of findings on metabolic and protein synthesis regulation by DDR.

Main Results:

• DDR actively rewires metabolic circuits in response to DNA damage.
• DDR influences protein synthesis, trafficking, and secretion.
• DDR balances cellular growth and defense mechanisms.

Conclusions:

• The DDR is a complex network extending beyond the nucleus.
• Active DDR signaling promotes cellular homeostasis and organismal survival.
• Understanding extranuclear DDR functions is crucial for health and disease research.