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Updated: Jul 26, 2026

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Studying DNA Looping by Single-Molecule FRET
Published on: June 28, 2014
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The influence of loops on the binding of the [Ru(phen)2dppz]2+ light-switch compound to i-motif DNA structures
Frederico R Baptista1, Stephen J Devereux, Sarah P Gurung
1School of Chemistry, University College Dublin, Dublin 4, Ireland. susan.quinn@ucd.ie.
Abstract:
Ultrafast time resolved infrared (TRIR) is used to report on the binding site of the "light-switch" complex [Ru(phen)2(dppz)]2+1 to i-motif structures in solution. Detailed information is provided due to perturbation of the local base vibrations by a 'Stark-like' effect which is used to establish the contribution of thymine base loop interactions to the binding site of 1 in this increasingly relevant DNA structure.
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