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Cholesteryl Ester Transfer Protein and Lipid Metabolism and Cardiovascular Diseases

Helena C F Oliveira1, Helena F Raposo2

  • 1Department of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, SP, Brazil. ho98@unicamp.br.

Advances in Experimental Medicine and Biology
|July 25, 2020
PubMed

Insights

Cholesteryl ester transfer protein (CETP) research has advanced significantly, impacting HDL cholesterol levels. Despite clinical trial setbacks, CETP inhibitors are still being investigated for anti-atherogenic effects in humans.

Area of Science:

  • Biochemistry
  • Cardiovascular Research
  • Pharmacology

Background:

  • Cholesteryl ester transfer protein (CETP) regulates high-density lipoprotein (HDL) plasma levels.
  • CETP's role in reverse cholesterol transport has been recognized since its initial characterization.
  • Early recognition of CETP's clinical importance spurred extensive research.

Purpose of the Study:

  • To review major advances in CETP research.
  • To discuss CETP's function in reverse cholesterol transport.
  • To analyze clinical trial outcomes for CETP inhibitors.

Main Methods:

  • Literature review of CETP research.
  • Analysis of genetic studies in animals and humans.
  • Examination of clinical trial data for CETP inhibition.

Main Results:

  • Conflicting results emerged from animal and human genetic studies.
  • Clinical trials investigating CETP inhibitors have faced significant setbacks.
  • Potential new functions of CETP are under exploration.

Conclusions:

  • CETP is a key modulator of HDL cholesterol.
  • CETP inhibition has shown mixed results in clinical trials.
  • The anti-atherogenic potential of CETP inhibitors in humans remains an active area of investigation.

Keywords:
CETP inhibitorsCardiovascular diseasesCholesteryl ester transfer protein (CETP)Lipid metabolismLipoprotein metabolism

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