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Related Concept Videos

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Related Experiment Video

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Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue
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Apolipoprotein M: Research Progress and Clinical Perspective.

Guanghua Luo1, Ning Xu2

  • 1Comprehensive Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou, People's Republic of China.

Advances in Experimental Medicine and Biology
|July 25, 2020
PubMed
Summary
This summary is machine-generated.

Apolipoprotein M (apoM) is a protein crucial for forming high-density lipoprotein (HDL), which helps remove cholesterol from arteries. ApoM also carries sphingosine-1-phosphate (S1P), contributing to HDL

Keywords:
Apolipoprotein MAtherosclerosisEndothelial cell barrierHigh-density lipoproteinInflammatorySphingosin-1-phosphate

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Area of Science:

  • Lipid metabolism and cardiovascular research
  • Biochemistry and molecular biology
  • Atherosclerosis and lipoprotein research

Background:

  • Apolipoprotein M (apoM) is a 23 kDa protein belonging to the lipocalin superfamily.
  • The human apoM gene is located on chromosome 6 within the major histocompatibility complex (MHC) class III locus.
  • ApoM is primarily expressed in hepatocytes and kidney tubular epithelium.

Purpose of the Study:

  • To investigate the role of apolipoprotein M (apoM) in high-density lipoprotein (HDL) metabolism and function.
  • To explore the association of apoM with antiatherogenic properties of HDL.
  • To elucidate the function of apoM as a carrier of sphingosine-1-phosphate (S1P).

Main Methods:

  • Characterization of apoM structure and gene location.
  • Analysis of apoM expression in human tissues.
  • Investigation of apoM's presence in different lipoprotein classes in plasma.
  • Assessment of apoM's role in HDL formation, particularly pre-beta HDL1.
  • Evaluation of apoM's function as an S1P carrier in vivo.

Main Results:

  • ApoM is critical for the formation of HDL, especially pre-beta HDL1.
  • ApoM is mainly found on HDL particles in human plasma but can associate with triglyceride-rich lipoproteins.
  • ApoM acts as a natural carrier of sphingosine-1-phosphate (S1P) in vivo.
  • These findings suggest apoM contributes to HDL's antiatherogenic, endothelial protective, and anti-inflammatory effects.

Conclusions:

  • Apolipoprotein M plays a vital role in HDL biogenesis and function.
  • ApoM's ability to carry S1P links it to HDL's diverse protective mechanisms against atherosclerosis.
  • Further research into apoM may reveal new therapeutic targets for cardiovascular diseases.