Related Experiment Video
Updated: Dec 14, 2025
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
9.6K
LDL and HDL Oxidative Modification and Atherosclerosis.
1Institute of Atherosclerosis, Shandong First Medical University, Taian, China. 13583815481@163.com.
Advances in Experimental Medicine and Biology
|July 25, 2020
Summary
Oxidative modification of lipoproteins like LDL and HDL impacts atherosclerosis development. While LDL cholesterol promotes AS, oxidized HDL may worsen the condition, highlighting its role in vascular health.
Area of Science:
- Biochemistry
- Cardiovascular Science
- Lipid Metabolism
Background:
- Low-density lipoprotein (LDL) and high-density lipoprotein (HDL) are key plasma lipoproteins.
- Elevated LDL cholesterol is linked to atherosclerosis (AS).
- Oxidative modification of lipoproteins is implicated in AS pathogenesis.
Purpose of the Study:
- To investigate the role of lipoprotein oxidative modification in vascular homeostasis.
- To clarify the dual role of HDL in relation to atherosclerosis.
Main Methods:
- Analysis of lipoprotein composition and oxidative states.
- Correlation studies between lipoprotein levels/modifications and AS markers.
- In vitro and in vivo models of vascular disease.
Main Results:
- LDL cholesterol levels positively correlate with atherosclerosis.
- Oxidatively modified HDL may not be protective and could exacerbate AS.
- Lipoprotein oxidation is a critical factor in vascular homeostasis.
Conclusions:
- Oxidative modification of lipoproteins is central to vascular homeostasis.
- Understanding lipoprotein oxidation is crucial for developing AS therapies.
Related Concept Videos
01:26Atherosclerosis III: Management
251
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
251
01:30Atherosclerosis I: Introduction
596
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
596
01:38Inflammation
60.9K
Overview
60.9K
01:26Coronary Artery Disease II: Pathophysiology
261
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
261
01:20Radical Autoxidation
2.8K
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
2.8K
01:30Coronary Artery Disease I: Introduction
748
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
748