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Updated: Dec 13, 2025

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
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Enzyme- or light-triggered cyclopropenes for bioorthogonal ligation

Ting Jiang1, Scott T Laughlin2

  • 1Department of Chemistry, Stony Brook University, Stony Brook, NY, United States.

Methods in Enzymology
|July 28, 2020
PubMed
Summary

Bioorthogonal reactions enable biological investigation. This review covers classic and new methods, highlighting light- or enzyme-activated "turn-on" cyclopropenes for in vitro and in vivo studies.

Keywords:
1,3-Dipolar cycloadditionAzideBODIPYBioorthogonal reactionsCaged cyclopropenesCoumarinCyclooctyneCyclopropeneEnzyme-triggered bioorthogonal reactionsFluorogenic probesLight-triggered bioorthogonal reactionsNitroreductaseStaudinger-Bertozzi ligationTetrazine

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