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Related Experiment Video

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Octreotide and lanreotide decrease ovarian ischemia-reperfusion injury in rats by improving oxidative and nitrosative

Senol Kalyoncu1, Bulent Yilmaz2, Mustafa Demir3

  • 1Obstetrics and Gynecology Clinic, TOBB ETU University Hospital, Ankara, Turkey.

The Journal of Obstetrics and Gynaecology Research
|August 5, 2020
PubMed
Summary

Octreotide and lanreotide protect against ovarian damage in a rat model of torsion and detorsion. These agents improved histopathological and biochemical markers, reducing oxidative stress and peroxynitrite levels.

Keywords:
ischemia-reperfusion injurylanreotideoctreotideoxidative stressperoxynitriterat ovarian torsion

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Area of Science:

  • Reproductive biology
  • Pharmacology
  • Toxicology

Background:

  • Ovarian ischemia-reperfusion injury (IRI) can lead to significant damage.
  • Surgical interventions like torsion and detorsion can induce ovarian IRI.
  • Pharmacological agents may offer protective effects against IRI.

Purpose of the Study:

  • To evaluate the protective effects of octreotide and lanreotide against ovarian damage.
  • To investigate the impact of these agents on histopathological and biochemical markers of IRI in a rat model.

Main Methods:

  • Fifty-six rats underwent a 3-hour torsion and detorsion procedure.
  • Rats were assigned to seven groups, including sham, control, and groups treated with octreotide or lanreotide at different time points.
  • Histopathological damage, total oxidant status, oxidative stress index, and peroxynitrite levels were assessed.

Main Results:

  • Octreotide and lanreotide treatments significantly reduced hemorrhage, degeneration, and total damage scores compared to the control group.
  • Both agents decreased total oxidant status and oxidative stress index.
  • Peroxynitrite levels were significantly reduced in specific treatment groups.

Conclusions:

  • Octreotide and lanreotide demonstrate a protective role in mitigating ovarian IRI.
  • These agents improve histopathological and biochemical outcomes by reducing oxidative stress and peroxynitrite.
  • The findings suggest potential therapeutic applications for these drugs in managing ovarian torsion-related damage.