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Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
Published on: November 17, 2014
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Coronavirus Disease 2019 in Solid Organ Transplant: A Multicenter Cohort Study
Olivia S Kates1, Brandy M Haydel2, Sander S Florman2
1Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.
Summary
Solid organ transplant recipients with COVID-19 faced a 20.5% mortality rate. Age and pre-existing conditions, not immunosuppression, were key factors in COVID-19 outcomes for these patients.
Area of Science:
- Transplantation Medicine
- Infectious Diseases
- Critical Care Medicine
Background:
- The COVID-19 pandemic impacted solid organ transplant (SOT) recipients, with concerns about severe disease outcomes.
- Limited data existed on the clinical characteristics, outcomes, and mortality predictors in SOT patients with COVID-19.
Purpose of the Study:
- To describe the clinical features and outcomes of SOT recipients diagnosed with COVID-19.
- To identify risk factors associated with 28-day mortality in hospitalized SOT recipients with COVID-19.
Main Methods:
- A multicenter cohort study involving SOT recipients with confirmed COVID-19.
- Standardized electronic case report forms were used for data collection and 28-day follow-up.
- Multivariable logistic regression analyzed risk factors for 28-day mortality.
Main Results:
- 482 SOT recipients were included, with 376 hospitalized.
- Among hospitalized patients, 20.5% died within 28 days.
- Independent predictors of mortality included age >65, congestive heart failure, chronic lung disease, obesity, lymphopenia, and abnormal chest imaging.
Conclusions:
- The 28-day mortality rate for hospitalized SOT recipients with COVID-19 was 20.5%.
- Mortality was primarily driven by patient age and underlying comorbidities.
- Immunosuppression intensity was not significantly associated with mortality.
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