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Updated: Dec 12, 2025

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The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

Alexander Hooftman1, Stefano Angiari1, Svenja Hester2

  • 1School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

Cell Metabolism
|August 14, 2020
PubMed

Keywords:
IL-1βNEK7NLRP3cysteine modificationimmunometabolisminflammasomeitaconatemacrophagemetabolitepyroptosis

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