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Updated: Dec 11, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Imidazole modified Pt(iv) prodrug-loaded multi-stage pH responsive nanoparticles to overcome cisplatin resistance
Xiaoxu Kang1, Yushu Wang, Zhigang Chen
1College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, P. R. China. yucy@mail.buct.edu.cn.
Abstract:
An imidazole modified Pt(iv) prodrug with a long lipid tail can assemble into multi-stage pH responsive nanoparticles via electrostatic complexation with a negatively charged hydrophilic polymer. This strategy could overcome cisplatin resistance significantly.
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