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[Analysis of genetic and environmental risk factors in pediatric OSA]

Huijun Wang1, Yanru Li1, Fei Gao1

  • 11Department of Otolaryngology Head and Neck Surgery，Beijing Tongren Hospital，Capital Medical University；Key Laboratory of Otolaryngology Head and Neck Surgery（Capital Medical University.

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology Head and Neck Surgery
|August 26, 2020
PubMed

Insights

Obstructive sleep apnea (OSA) in children who habitually snore is linked to apnea symptoms, higher BMI z-scores, and a mother

Area of Science:

  • Pediatric Sleep Medicine
  • Genetics and Environmental Health
  • Respiratory Disorders

Background:

  • Habitual snoring in children is a common concern.
  • Identifying risk factors for obstructive sleep apnea (OSA) is crucial for early intervention.
  • Understanding the interplay of genetic and environmental factors in pediatric OSA is essential.

Purpose of the Study:

  • To investigate genetic and family environmental risk factors for OSA in children with habitual snoring.
  • To differentiate risk profiles between children with simple snoring and those with OSA.

Main Methods:

  • Recruitment of children with habitual snoring undergoing overnight polysomnography (PSG).
  • Classification of subjects into snoring and OSA groups based on ICSD-3 criteria.
  • Comparative analysis of demographic, clinical, and family environmental factors using binary logistic regression.

Main Results:

  • Apnea symptoms, elevated BMI z-score, and maternal history of tonsillitis/adenotonsillectomy were significant risk factors for OSA.
  • Odds ratios for these factors were 4.081, 1.347, and 3.897, respectively.
  • No significant differences were found in environmental factors like residence, income, or parental smoking.

Conclusions:

  • Pediatric OSA in habitual snorers is associated with specific clinical and maternal medical history factors.
  • Higher BMI z-score is a key indicator for OSA risk in this population.
  • Maternal history of recurrent tonsillitis or tonsillectomy may indicate a genetic predisposition or shared environmental influence.

Keywords:
childrenrisk factorssleep apnea, obstructive

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