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Related Concept Videos

The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
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In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
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Extracellular Matrix01:26

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Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
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The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at either end of the microtubule or in the microtubule lattices as a whole. The lifespan of individual microtubules within a cell varies according to the cell type and stage of the cell cycle. During interphase, the lifespan of the microtubule is about 30 minutes, while during cell division, it is about 15 minutes. In axonal microtubules of...
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Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
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Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

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Elastin in the Tumor Microenvironment.

Yihong Wang1, Elizabeth C Song2, Murray B Resnick3

  • 1Department of Pathology and Laboratory Medicine, Rhode Island Hospital and Lifespan Medical Center, Warren Alpert Medical School of Brown University, Providence, RI, USA. yihong_wang@brown.edu.

Advances in Experimental Medicine and Biology
|August 27, 2020
PubMed
Summary
This summary is machine-generated.

Elastic fibers play a dual role in cancer, influencing tumor growth and metastasis. Targeting elastin degradation products and utilizing elastin-like peptides offer promising anti-cancer therapeutic strategies.

Keywords:
ElastaseElastic fiberElastinElastin collagen cross-linkingElastin receptorElastin-binding proteinElastin-derived peptideElastin-like peptideElastomaElastosisExtracellular matrixLysyl oxidasesNeutrophil elastaseTumor microenvironmentTumor-associated stroma

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Area of Science:

  • Biochemistry
  • Oncology
  • Extracellular Matrix Biology

Background:

  • Elastic fibers, composed of elastin, are crucial for tissue resilience and are integral to the extracellular matrix (ECM).
  • Elastin and its degradation products are implicated in various aspects of cancer, including tumor growth, invasion, and metastasis.
  • The tumor microenvironment often exhibits remodeled ECM with altered elastin levels, impacting oncogenesis.

Purpose of the Study:

  • To explore the multifaceted roles of elastin and its derivatives in cancer progression.
  • To investigate the potential of targeting elastin-related enzymes and peptides for anti-cancer therapies.
  • To evaluate elastin-like peptides (ELP) and elastin-derived peptides (EDP) as therapeutic agents and drug delivery systems.

Main Methods:

  • Review of existing literature on elastin's role in cancer.
  • Analysis of elastin cross-linking and enzymatic degradation in tumorigenesis.
  • Examination of the impact of elastin-derived peptides (EDP) on tumor development and metastasis.
  • Assessment of elastin-like peptides (ELP) for direct anti-cancer activity and drug delivery applications.

Main Results:

  • Elevated elastin in malignancies can either promote or inhibit tumor growth.
  • Neutrophil elastase and other elastases are key drivers of cancer invasion and metastasis.
  • Elastin degradation generates bioactive fragments (EDPs) that modulate tumor progression.
  • EDPs and their binding proteins are critical targets for novel anti-cancer therapies.
  • ELPs show potential as drug carriers and direct anti-cancer agents.

Conclusions:

  • Elastin and its degradation products are significant players in cancer biology, offering therapeutic targets.
  • Targeting elastases and EDPs presents a promising strategy for inhibiting cancer metastasis.
  • Elastin-like peptides (ELPs) hold potential for both direct anti-cancer effects and advanced drug delivery systems.