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Updated: Dec 9, 2025

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
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Atrioventricular and Sinus Node Dysfunction in Stable COVID-19 Patients

Savalan Babapoor-Farrokhran1, Uyanga Batnyam1, Philip C Wiener1

  • 1Division of Cardiology, Department of Medicine, Einstein Medical Center, 5501 Old York Road, Philadelphia, PA 19141 USA.

SN Comprehensive Clinical Medicine
|September 9, 2020
PubMed

Insights

COVID-19 can cause cardiac complications, including arrhythmias. This study highlights two patients who developed cardiac conduction abnormalities, specifically sino-atrial and atrioventricular node disease, following SARS-CoV-2 infection.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Virology

Background:

  • COVID-19 is associated with various cardiac complications, including myocarditis, heart failure, and acute coronary syndromes.
  • Arrhythmias are increasingly recognized as significant complications of SARS-CoV-2 infection.

Purpose of the Study:

  • To investigate the potential link between SARS-CoV-2 infection and cardiac conduction abnormalities.
  • To report cases of cardiac conduction system disease in patients with COVID-19.

Main Methods:

  • Case report of two patients presenting with COVID-19 symptoms and confirmed SARS-CoV-2 infection.
  • Clinical evaluation of cardiac conduction abnormalities in affected patients.

Main Results:

  • Both patients developed cardiac conduction abnormalities after COVID-19 diagnosis.
  • The observed abnormalities involved the sino-atrial (SA) node and atrioventricular (AV) node.

Conclusions:

  • Cardiac conduction system disease affecting the SA and AV nodes may be a manifestation of SARS-CoV-2 infection.
  • These findings suggest a potential direct or indirect impact of COVID-19 on the heart's electrical system.

Keywords:
ArrhythmiaAtrioventricular blockBradycardiaCOVID-19Sinus node dysfunction

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