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Optimized methods for production and purification of Titanium-45.
Ivis F Chaple1, Kathryn Thiele1, Grace Thaggard1
1Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Summary
Titanium-45 (45Ti) shows potential as a PET imaging agent due to its ideal nuclear properties. Researchers successfully produced 45Ti in significant amounts, paving the way for future radiopharmaceutical development.
Area of Science:
- Nuclear chemistry and radiopharmaceutical science.
Background:
- Titanium-45 (45Ti) possesses favorable nuclear characteristics for Positron Emission Tomography (PET) imaging.
- Key properties include a high positron branching ratio (85%) and low average positron energy (0.439 MeV).
Purpose of the Study:
- To evaluate Titanium-45 (45Ti) as a viable radiometal for PET imaging applications.
- To establish production and purification methods for 45Ti.
Main Methods:
- Production of 45Ti via the 45Sc(p,n)45Ti nuclear reaction using a TR24 cyclotron.
- Development of optimized separation and purification techniques for the radiometal.
- Conducting preliminary radiochemistry studies.
Main Results:
- GBq quantities of 45Ti were successfully produced.
- Optimized separation methods were established.
- Preliminary radiochemistry confirmed the feasibility of using 45Ti.
Conclusions:
- Titanium-45 (45Ti) is a promising radiometal for the development of novel PET imaging agents.
- The established production and separation methods support its future use in radiopharmaceutical research.
