Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Papillary Dermis

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Changes in estimands and prevalence of discrepancies in conclusions under the two-trial paradigm: a systematic review.

Journal of clinical epidemiology·2026

Same author

Time to diagnosis and treatment of obstructive sleep apnoea using mandibular jaw movement monitoring versus polysomnography: an open-label, multicentre, randomised, controlled trial.

The Lancet regional health. Europe·2026

Same author

Cyclin-dependent kinase inhibitors and kidney injury: Analysis of the French pharmacovigilance database.

Therapie·2026

Same author

Netrin1 blockade alleviates resistance to chemotherapy in pancreatic cancer.

Nature·2026

Same author

Comparison of the effect of donepezil and a combination of donepezil and mefloquine (THN201) on cognition during a scopolamine challenge in healthy participants.

Experimental and clinical psychopharmacology·2026

Same author

Endothelial cell senescence and mitochondrial dysfunction in vascular ageing.

Ageing research reviews·2026

Same journal

Heart-Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes.

Comprehensive Physiology·2026

Same journal

The Adipose-Organ Communication Network in Clinical Obesity: From Adiposopathy to Systemic Metabolic Failure.

Comprehensive Physiology·2026

Same journal

Insight Into the Biological Link Between Novel Adiposity Indices and Incident Heart Failure.

Comprehensive Physiology·2026

Same journal

Domino Effect of the Kynurenine Pathway: Systemic Homeostasis, Metabolic Crosstalk, and Therapeutic Potential.

Comprehensive Physiology·2026

Same journal

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases.

Comprehensive Physiology·2026

Same journal

Sleep Disturbances and Male Reproductive Dysfunction: Pathophysiological Mechanisms Linking Obstructive Sleep Apnea and Sleep Deprivation.

Comprehensive Physiology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 8, 2025

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

Human Skin Microcirculation.

Jean-Luc Cracowski¹, Matthieu Roustit¹

¹University of Grenoble Alpes, Grenoble, France.

Comprehensive Physiology

|September 17, 2020

Summary

This summary is machine-generated.

Human skin microcirculation involves complex interactions of nerves and vessels for blood flow regulation. Understanding these mechanisms is key to addressing cardiovascular and skin diseases.

More Related Videos

Bioengineering Human Microvascular Networks in Immunodeficient Mice

Bioengineering Human Microvascular Networks in Immunodeficient Mice

Published on: July 11, 2011

Non-invasive Assessment of Microvascular and Endothelial Function

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

Related Experiment Videos

Last Updated: Dec 8, 2025

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

Bioengineering Human Microvascular Networks in Immunodeficient Mice

Bioengineering Human Microvascular Networks in Immunodeficient Mice

Published on: July 11, 2011

Non-invasive Assessment of Microvascular and Endothelial Function

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

Area of Science:

Physiology
Dermatology
Cardiovascular Science

Background:

Human skin microcirculation is organized into two parallel plexuses with perpendicular capillary loops.
Physiological regulation involves sympathetic activation (vasoconstriction) and cholinergic systems (vasodilation).

Purpose of the Study:

To detail the anatomy and physiology of human skin microcirculation.
To discuss methods for exploring microcirculation.
To examine the role of microvascular impairment in disease pathophysiology.

Main Methods:

Review of anatomical and physiological mechanisms.
Discussion of regulatory pathways including neural and endothelial factors.
Exploration of diagnostic methods for microcirculation assessment.

Main Results:

Cutaneous microcirculation is regulated by sympathetic, cholinergic, and sensory nerves, as well as endothelial factors and myogenic responses.
Complex interactions between these mechanisms determine skin blood flow.
Impaired microcirculation is implicated in cardiovascular and metabolic diseases.

Conclusions:

Human skin microcirculation is a complex system with multiple regulatory inputs.
Understanding these intricate mechanisms is crucial for diagnosing and treating related diseases.
Further research into microvascular function can illuminate disease pathways.