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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Emergency Transfusions

Michael S Farrell1, Woon Cho Kim2, Deborah M Stein2

  • 1Department of Surgery, University of California San Francisco, 1001 Potrero Avenue, Ward 3A, San Francisco, CA 94110, USA; Zuckerberg San Francisco General Hospital, San Francisco, CA, USA. Electronic address: https://twitter.com/mfarrellmd.

Emergency Medicine Clinics of North America
|September 28, 2020
PubMed

Successful emergency transfusions require early recognition and activation of resources to minimize treatment delays. The initial goals should focus on replacement of blood in a balanced fashion. There is an ongoing debate regarding the best approach to transfusions, with some advocating for resuscitation with a fixed ratio of blood products and others preferring to use viscoelastic assays to guide transfusions. Whole-blood transfusion also is a debated strategy. Despite these different approaches, it generally is accepted that transfusions should be started early and crystalloid infusions limited. As hemodynamic stability is restored, endpoints of resuscitation should be used to guide the resuscitation.

Keywords:
BloodCoagulopathyResuscitationTransfusion

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