Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.1K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

580
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
580
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

17.6K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.6K
Factors Affecting Illness01:18

Factors Affecting Illness

4.8K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
4.8K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.8K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.8K
Infection01:20

Infection

11.2K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Artificial Intelligence (AI) paradox.

Bioinformation·2026
Same author

Risk group-4 virus emergent threats.

Bioinformation·2025
Same author

Regulation of inflammaging.

Bioinformation·2025
Same author

Protein disorder - function paradigm: Putative role in inflammation.

Bioinformation·2025
Same author

Artificial intelligence in systemic diagnostics: Applications in psychiatry, cardiology, dermatology and oral pathology.

Bioinformation·2025
Same author

Integrating MICRORNA941 and T cell subset research into public health strategies for managing inflammaging in elderly and immune-compromised patients.

Bioinformation·2025
Same journal

Assessment of lower incisor position and symphysis dimensions among different skeletal patterns in the Chhattisgarh population.

Bioinformation·2026
Same journal

Low T3 syndrome and short-term outcomes in patients with acute decompensated heart failure: A retrospective observational study.

Bioinformation·2026
Same journal

Cardiovascular risk prevention awareness and practices in type 2 diabetes: Linking HbA1c and lipid levels.

Bioinformation·2026
Same journal

Assessment of periodontal condition using basic periodontal examination scores: A retrospective clinical study.

Bioinformation·2026
Same journal

Comparative evaluation of osseointegration among different surface modification techniques in dental implants.

Bioinformation·2026
Same journal

Micro-osteoperforations' impact on orthodontic tooth movement rate: Split mouth research.

Bioinformation·2026
See all related articles

Related Experiment Video

Updated: Dec 7, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.6K

CoViD-19 Susceptibility.

Francesco Chiappelli1

  • 1Francesco Chiappelli, Ph.D., Dr. Endo (h.c), Professor Emeritus, UCLA, Center for the Health Sciences; CSUN, Department of the Health Sciences.

Bioinformation
|September 30, 2020
PubMed
Summary
This summary is machine-generated.

Genetic variations in ACE2 and TMPRSS2 may influence COVID-19 severity. These host factors, affecting the SARS-CoV-2 spike protein

Keywords:
COVID-19immunitysusceptibility

More Related Videos

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.1K
Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.6K

Related Experiment Videos

Last Updated: Dec 7, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.6K
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.1K
Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.6K

Area of Science:

  • Virology
  • Genetics
  • Immunology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has led to millions of infections and deaths globally.
  • Understanding factors influencing COVID-19 patient outcomes, including survival and severity, is crucial for developing effective treatments and vaccines.
  • The SARS-CoV-2 virus infects host cells via its spike (S) protein binding to the ACE2 receptor, with TMPRSS2 facilitating viral entry.

Discussion:

  • SARS-CoV-2 infects host cells via its spike (S) protein binding to the ACE2 receptor.
  • The S protein is cleaved by TMPRSS2, facilitating viral entry into host cells.
  • Genetic variations in ACE2 and TMPRSS2 may alter their interaction with the S protein.

Key Insights:

  • Single nucleotide polymorphisms (SNPs) in ACE2 and genetic variants of TMPRSS2 are being investigated.
  • These genetic variations may influence the affinity for S protein cleavage.
  • This could contribute to a spectrum of SARS-CoV-2 virulence and COVID-19 susceptibility among patients.

Outlook:

  • Further research into host genetic factors can elucidate mechanisms of viral pathogenesis.
  • Understanding these variations may aid in predicting patient outcomes and developing targeted therapies.
  • Identifying genetic predispositions could inform personalized medicine approaches for infectious diseases.